Atmospheric Seeding Kills Drug Forms

Some pharmaceutical crystal forms (polymorphs) can be globally supplanted because more stable polymorph seeds—microscopic nuclei—spread across labs and the environment, causing the faster‑forming but earlier approved form to vanish from production. This process can force reformulations, halt supplies, and trigger costly litigation and public‑health gaps. — If true and common, atmospheric or cross‑lab seeding of stable polymorphs is a systemic supply‑chain risk that affects drug availability, patent disputes, regulatory approvals, and how regulators and manufacturers certify reproducibility.