Autoimmunity‑Inspired Universal Antivirals

Researchers show that temporarily emulating the ISG15‑deficiency immune state can protect human cells and animals against multiple viruses (e.g., Zika, SARS‑CoV‑2). By targeting the host’s interferon‑regulation pathway instead of each virus, this strategy could create a new class of broad‑spectrum antivirals for outbreak stockpiles. Safety will hinge on dialing antiviral benefits without triggering harmful inflammation. — Host‑directed, universal antivirals would reshape pandemic readiness beyond strain‑specific vaccines, influencing funding, regulatory pathways, and biodefense strategy.