BBB Repair Clears Alzheimer’s Plaques

Researchers from Spain and China repaired the blood–brain barrier in Alzheimer’s‑model mice, enabling the brain to rapidly clear amyloid‑beta. Within hours of the first dose, plaques fell ~45%, and after three injections mice performed like healthy controls; benefits lasted at least six months. This reframes the BBB as a drug target that can unlock the brain’s own clearance pathways. — If validated in humans, targeting vascular/BBB integrity could complement or replace antibody therapies and shift Alzheimer’s policy and funding toward vascular repair mechanisms.