Require a short, machine‑readable provenance statement and audit trail for every clinical trial submitted to journals or regulators (including protocol registration timestamp, raw/processed data access plan, who curated data, and key statistical code). Coupled with mandatory IPD submission or escrow and routine automated consistency scans, this would make trial claims auditable before they enter guidelines or press coverage.
— Making provenance and data‑access mandatory would materially reduce the risk that fabricated or irreproducible clinical trials influence medical practice, regulatory approvals, and public health policy.
2023.07.18
100% relevant
Nature cites estimates (e.g., Carlisle’s work) and calls for stronger scrutiny of trial integrity — the article’s concrete complaint (≥25% problematic trials in some fields) motivates a provenance and IPD‑first policy.
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