Dichotomania Distorts Genetic Risk

Updated: 2026.03.05 2H ago 1 sources
Medical and commercial genetics often convert continuous traits into binary 'disease' labels using arbitrary thresholds; when embryo selection nudges a trait slightly, modelers can present large relative risk reductions even though individuals experience negligible clinical change. This statistical sleight‑of‑hand (which the author calls 'dichotomania') systematically misleads consumers and policymakers about the real value of selecting embryos by polygenic scores. — If regulators, clinicians, and prospective parents accept threshold‑based risk claims without scrutiny, embryo selection could be normalized on a false basis, shaping reproductive choices and inequality while producing little health gain.

Sources

What we talk about when we talk about risk - by Sasha Gusev
2026.03.05 100% relevant
The article's BMI>40 example, simulations using within‑family polygenic score variance (9% explained), and citation of Karavani et al. (2019) concretely illustrate how small mean shifts produce large percent reductions under the liability threshold model.
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