Edit rare variants for human traits

Rather than trying to tweak millions of common DNA markers with tiny effects, engineers should look for rare genetic variants with outsized, tractable impacts and target those for therapeutic edits or embryo selection. This is presented as a faster, more effective route to changing complex traits — but it concentrates risk, power, and inequality in the hands of those who control variant discovery and editing pipelines. — Shifting emphasis to rare‑variant editing changes which actors, regulations, and ethical debates matter — from broad polygenic governance to oversight of variant discovery, commercialization, and single‑variant interventions.