Many clinical 'biological age' algorithms built from electronic health records mainly recapitulate chronological‑age‑related risk signals and dataset artifacts, so their cross‑sectional accuracy (e.g., AUCs) does not prove they track a causal, modulable aging process. Deploying them as intervention targets or in hospital systems without longitudinal, within‑person validation risks misdirecting care, regulatory decisions, and research funds.
— If true, hospitals, regulators, and consumers may be adopting and paying for tools that don't measure a treatable biological process but instead codify age‑and‑cohort risk, with consequences for clinical practice, health equity, and longevity research prioritization.
Cremieux
2026.11.03
100% relevant
LinAge2 (npj Aging 2025) — trained on NHANES 1999–2000, tested on 2001–02, uses principal components of ~60 EHR inputs and reports AUC=0.868 vs age-only 0.829; slated for Singapore hospital deployment.
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