A sibling donor unexpectedly carrying a protective CCR5‑Δ32 mutation enabled a stem‑cell transplant that appears to have cured an HIV patient — the first documented family‑donor cure. This suggests family screening could occasionally identify rare protective genotypes and affect donor selection strategies for curative transplants.
— It implies concrete changes to donor screening, ethical debates over genetic testing of relatives, and potential pressure to use gene editing or donor selection in cure strategies.
BeauHD
2026.04.15
100% relevant
Norwegian case: 63‑year‑old with HIV and myelodysplastic syndrome received brother's stem cells; brother was found to be CCR5‑Δ32 homozygous on transplant day; patient off antiretroviral therapy for two years with no detectable virus.
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