Family donors expand HIV cures

Updated: 2026.04.15 6H ago 1 sources
A sibling donor unexpectedly carrying a protective CCR5‑Δ32 mutation enabled a stem‑cell transplant that appears to have cured an HIV patient — the first documented family‑donor cure. This suggests family screening could occasionally identify rare protective genotypes and affect donor selection strategies for curative transplants. — It implies concrete changes to donor screening, ethical debates over genetic testing of relatives, and potential pressure to use gene editing or donor selection in cure strategies.

Sources

Norway Man Cured of HIV With Brother's Stem Cells
BeauHD 2026.04.15 100% relevant
Norwegian case: 63‑year‑old with HIV and myelodysplastic syndrome received brother's stem cells; brother was found to be CCR5‑Δ32 homozygous on transplant day; patient off antiretroviral therapy for two years with no detectable virus.
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