PGS predict intelligence and school outcomes much more strongly across unrelated people than they do between siblings; the within‑family (dizygotic twin difference) estimates are substantially smaller, indicating that ancestral, mating, or shared‑family processes amplify population‑level PGS signals. That gap is measurable across childhood to early adulthood in the UK Twins Early Development Study sample.
— If PGS effects are partly family‑level rather than individual, policymakers and journalists should be cautious about using PGS as indicators of individual ability or as justification for interventions like embryo selection or educational sorting.
2026.11.03
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Authors Lin et al. (including Robert Plomin) report within‑family versus population PGS comparisons using UK Twins Early Development Study (6,972 unrelated individuals; 3,306 dizygotic twin pairs) and present within‑to‑population effect ratios showing attenuation within families.
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