Early mouse studies now suggest in‑vitro fertilization can induce epigenetic changes that not only persist but intensify across generations in lab animals. While first‑generation clinical risks are modest and IVF’s social value is high, the possibility of cumulative transgenerational effects raises questions for long‑term monitoring, regulation, and informed consent.
— If IVF‑related epigenetic changes compound across generations, reproductive‑health policy, fertility counseling, and population‑level health planning will need new long‑term evidence and oversight frameworks.
Erik Hoel
2026.04.02
100% relevant
Cited papers: a Nature Communications cloning study and a separate mouse study titled 'In vitro fertilization induces reproductive changes in male mouse offspring and has multigenerational effects' (both highlighted in the article).
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