A modern height polygenic score derived from present‑day GWAS (Yengo et al.) predicts skeletal stature in ancient European individuals: in a sample of 459 matched genomes and bones the author estimates ≈3.1–3.3 cm of stature per one standard deviation of the score after controlling for sex, date, study and ancestry structure. The relationship survives a genetic relationship matrix (GRM) test, indicating that PGS portability into deep time is empirically testable and non‑trivial.
— If modern PGS reliably predict past phenotypes, historians, anthropologists and policy debates about genetic differences gain a quantitative tool — but also a new flashpoint for discussions about the stability, interpretation, and misuse of genetic prediction across populations and eras.
Davide Piffer
2026.11.05
100% relevant
The article’s empirical result: 459 ancient individuals matched to skeletal stature with PGS computed using Yengo et al. weights, yielding ≈3.3 cm per PGS SD and robustness to a GRM ancestry control.
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