Renewed emphasis on single-gene, large-effect edits (e.g., protective or performance variants) as the practical route to human enhancement, supplanting polygenic editing ambitions.
— Shifts bioethics, regulation, and risk assessment toward near-term, technically feasible edits that can be framed as preventive or protective, influencing public acceptance and oversight priorities.
Davide Piffer
2025.07.30
100% relevant
The article frames George Church’s 51-gene catalog as a blueprint for enhancement and argues single variants can ‘rewrite’ human traits, contrasting with polygenic score strategies.
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