One‑quarter of clinical trials questionable

Investigations summarized in Nature report that, in some fields, about 25% of published clinical trials show patterns consistent with serious problems or fabrication. The piece calls for stronger scrutiny, improved auditing, and procedural changes to trial registration, data access and peer review. — If a large share of trials are unreliable, medical guidance, regulatory decisions and patient care built on those trials may be systematically biased and unsafe.