Personality PGSs Often Don’t Travel

Using the new Nature personality GWAS lead variants and multiple global genetic frequency panels, a researcher shows that most personality polygenic scores fail to predict average national self‑reported personality consistently across datasets and reference‑group effects. Only one trait remained robust across every test, suggesting portability is trait‑specific and fragile. — If personality polygenic scores lack cross‑population portability, claims about genetic bases for national or ethnic personality differences are much less defensible and could reshape debates about genetics, identity, and public policy.