Protective‑allele editing playbook

A compact catalog of human genetic variants with known protective or enhancing effects (with notes on harms) can serve as a practical playbook for translating protective alleles into therapies or enhancements via gene editing. That playbook changes the debate from abstract risk to concrete choices — which variants to target, which tradeoffs to accept, and who gains access. — Making a checklist of candidate protective alleles reframes ethical and policy debates by turning speculative enhancement into an actionable public‑health and regulation problem.