Rare‑variant engineering playbook

Rather than attempting to edit the vast number of common markers that modestly correlate with complex traits, prioritize discovery, validation, and safe manipulation of rare, high‑effect variants as the practical path to meaningful genetic enhancement. This approach leverages falling sequencing costs and rare‑variant discovery tools to create a staged 'genomic stack' product roadmap from diagnosis to targeted editing. — If adopted, this tactical framing shifts regulatory focus, accelerates ethical questions about enhancement access and risk, and raises concrete biosecurity and inequality concerns that policymakers must address now.