Cremieux
2026.11.03
87% relevant
The article’s core claim is that many aging clocks (exemplified by LinAge2) may be risk scores driven largely by chronological age and cohort structure rather than modulable biological processes; that directly maps to the existing idea that interventions and claims about biological-age measures need within-person (longitudinal/causal) validation before being used as targets — the author cites NHANES-based train/test design, AUC comparisons, and the planned Singapore clinical deployment as concrete reasons why cross‑sectional performance is insufficient.
Cremieux
2026.03.25
100% relevant
Cremieux's reanalysis of Nagata et al.'s ABCD study (Lancet Regional Health Americas) and his note that authors could have used within‑person and sibling fixed‑effects but instead reported group‑trajectory between‑person estimates.