A Japanese national study applied sibling controls, inverse‑probability weighting, propensity matching, negative controls, E‑values, and probabilistic sensitivity analysis and found no Tylenol–autism link. This shows how pre‑specified robustness tests can vet observational pharmacoepidemiology before it is used in guidance.
— Agencies should require transparent robustness maps (negative controls, E‑values, sensitivity bounds) before issuing public health warnings based on observational data to avoid misleading policy.
Theodore Dalrymple
2025.10.14
70% relevant
By invoking Bradford Hill criteria and warning against multiple‑comparison artifacts, the piece supports the principle that agencies and leaders should require pre‑specified robustness checks before issuing drug‑safety cautions—precisely the governance fix proposed for observational pharmacoepidemiology.
Cremieux
2025.10.03
100% relevant
The Japan administrative database study (2005–2022; 182,830 mothers, 217,602 children) coupled sibling design with negative controls and E‑values and reported null effects.
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