Senescent macrophages drive fatty liver

Researchers identified liver macrophages marked by p21 and TREM2 that become senescent with age or high LDL cholesterol, promote inflammation, and accumulate to very high levels in older mice. Clearing these cells with a senolytic drug reversed liver enlargement, inflammation and produced substantial weight loss in diet‑fed mice, even without changing the diet. — If confirmed and translated, targeting cholesterol‑induced immune senescence could reshape treatments for fatty liver disease, age‑related inflammation, and the regulatory debate over senolytic drugs.