Require that any study or meta‑analysis reporting antidepressant discontinuation outcomes present severity‑weighted metrics (not just symptom counts) and relate them to functional impairment (e.g., days disabled, care sought, work disruption). Journals and agencies should mandate at least one graded symptom scale or an agreed composite that maps new/worsened symptoms to real‑world impairment before policymakers treat findings as grounds for broad guidance.
— Standardizing severity‑focused reporting would prevent misinterpretation of small, numerous but minor symptoms as evidence of large clinical harm, thereby improving clinical consent, regulatory decisions, and public communication.
2026.01.05
100% relevant
Kalfas et al.’s heavy reliance on the DESS—which assigns one point per symptom and does not capture severity—is the concrete example showing why counts alone mislead and why severity‑weighted reporting is needed.
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