Single‑dose psilocybin boosts neuroplasticity

A Nature Communications study of 28 psychedelic‑naive adults found that one 25 mg psilocybin session produced an acute surge in EEG entropy during the trip, subjective psychological insight and improved cognitive flexibility for at least a month, and imaging evidence of increased dendritic density — suggestive (but not yet definitive) of increased neuroplasticity after a single experience. Researchers link the entropic brain state during the trip to later gains in well‑being, arguing the phenomenological episode itself is a key therapeutic ingredient. — If replicated, this reframes psychedelic therapy policy and clinical design by centering the acute psychedelic experience and its neural correlates as causal mechanisms for sustained mental‑health benefits.