Stopping GLP‑1s Raises Cardiovascular Risk

Updated: 2026.03.18 3H ago 1 sources
A BMJ Medicine study of 333,000 U.S. veterans with type‑2 diabetes found pausing GLP‑1 therapy for as little as six months increased heart attack and stroke risk, with up to a 22% higher risk after two years off the drug; restarting restored only part of the protection. The author argues adherence should be treated as a primary clinical outcome and that GLP‑1 prescriptions may imply long‑term or indefinite treatment commitments. — If true broadly, the finding shifts debates over GLP‑1 access, insurance coverage, informed consent, and long‑term care planning because stopping treatment is not just a cosmetic or weight‑regain issue but a cardiovascular risk issue.

Sources

“Whiplash”: Heart Attack and Stroke Risk Jumps When People Stop Taking GLP-1s
Jake Currie 2026.03.18 100% relevant
BMJ Medicine study led by Ziyad Al‑Aly tracking >333,000 U.S. veterans; reported up to 22% increased risk after two years off GLP‑1s and 18% vs 12% risk reductions for continuous users vs restarters.
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