The new JAMA Psychiatry review finds only about one extra discontinuation symptom after stopping antidepressants, but it relies on DESS, a checklist that assigns one point per symptom and does not rate how bad it is. A small increase in symptom counts can still mask highly disabling cases that matter most for patients and policy. Treating this as 'reassuring' risks complacency about tapering and support.
— If measurement tools undercount severity, guidelines, media, and insurers may misjudge withdrawal risks and undermine safe deprescribing practices.
2025.10.07
100% relevant
The paper’s Supplementary Materials state DESS does not grade severity; Aftab cautions against drawing safety conclusions from a +1 DESS finding in Kalfas et al. (JAMA Psychiatry, 2025).
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