Weight Regain After GLP‑1s

A synthesis of existing studies finds many patients regain lost weight within two years after stopping GLP‑1 class weight‑loss medications, at a faster rate than after lifestyle‑based weight loss. This implies that for durable BMI reduction, health systems may need to plan for long‑term or indefinite treatment, monitoring of metabolic outcomes, and cost‑sharing decisions. — The finding reframes debates over obesity treatment from a short‑course pill narrative to questions about chronic‑disease management, budgetary liability for insurers/governments, and realistic public messaging on what 'successful' weight‑loss therapy requires.