Ancestry Paradox in Polygenic Scores

Polygenic scores trained on European datasets underperform in non‑European populations, yet institutions often deny biologically meaningful group differences. Embryo‑selection tools thus work best for Europeans, creating a two‑tier system while exposing a contradiction between practice and prevailing narratives. — It forces regulators, clinicians, and media to confront ancestry‑specific performance and its ethical and political implications for equity and how we talk about race and genetics.