Regional PGS reflect environment too

Updated: 2025.03.26 7M ago 1 sources
Averaging polygenic scores across regions can pick up environmental differences, not just genetics. The paper cautions that geographic PGS maps may be misread as innate group differences when they partly capture schooling, mobility, disease spread, and other context. — This warns media and policymakers against genetic determinism in regional comparisons and urges more careful interpretation of population genomics in public debates.

Sources

Socio-economic status is a social construct with heritable components and genetic consequences | Nature Human Behaviour
2025.03.26 100% relevant
Fig. 3 in the paper: 'Polygenic prediction of average phenotypes per region probably captures environmental influences.'
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