Socioeconomic inflation of polygenic prediction

Updated: 2026.04.04 1H ago 1 sources
Using dizygotic twin differences versus unrelated individuals in a UK cohort, the authors show that roughly half of PGS predictive power for intelligence and educational traits stems from between-family processes — chiefly socioeconomic status — rather than individual-level inheritance. That contrasts with traits like height and BMI where within-family (direct) genetic effects account for most population prediction. — If PGS-based predictions partly reflect family environment and mating/ancestry patterns (not just individual genetics), using them in education, hiring, or insurance risks conflating social circumstance with innate ability.

Sources

Polygenic Score Prediction Within and Between Sibling Pairs for Intelligence, Cognitive Abilities, and Educational Traits From Childhood to Early Adulthood | Published in Intelligence & Cognitive Abilities
2026.04.04 100% relevant
UK Twins Early Development Study (6,972 unrelated individuals and 3,306 dizygotic twin pairs) and authors' finding that socioeconomic status largely explains between-family PGS effects.
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