Using dizygotic twin differences versus unrelated individuals in a UK cohort, the authors show that roughly half of PGS predictive power for intelligence and educational traits stems from between-family processes — chiefly socioeconomic status — rather than individual-level inheritance. That contrasts with traits like height and BMI where within-family (direct) genetic effects account for most population prediction.
— If PGS-based predictions partly reflect family environment and mating/ancestry patterns (not just individual genetics), using them in education, hiring, or insurance risks conflating social circumstance with innate ability.
2026.04.04
100% relevant
UK Twins Early Development Study (6,972 unrelated individuals and 3,306 dizygotic twin pairs) and authors' finding that socioeconomic status largely explains between-family PGS effects.
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