Two‑Year Hormones Improve Youth Psychosocials

A multicenter observational NEJM study followed transgender adolescents for two years after starting gender‑affirming hormone therapy and found improvements in measures of depression, anxiety, and overall psychosocial functioning. The study is not randomized, so results show association rather than definitive causation and are subject to selection and confounding biases. — This multi‑clinic, two‑year evidence influences policy and legal debates about adolescent access to gender‑affirming care and highlights the need to weigh observational benefits against methodological limits when setting guidelines.