A large GREML‑WGS analysis of 347,630 UK genomes finds whole‑genome data (including rare variants) captures roughly 88% of pedigree‑based narrow‑sense heritability across dozens of traits, meaning most of the formerly 'missing heritability' is detectable with sufficiently dense sequencing and sample size. The result reconciles pedigree and molecular estimates and changes what genetic prediction and causal inference can plausibly achieve.
— If reproducible, this settles a decades‑old empirical dispute and forces policymakers, educators, and clinicians to reckon with genetically informed prediction and its ethical, legal, and social consequences.
Scott Alexander
2025.12.03
100% relevant
Wainschtein, Yengo et al., GREML‑WGS on 347,630 British whole genomes reporting ~88% recovery of pedigree heritability for 34 traits.
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